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The Core 4: The Foundation Every GLP-1 Journey Is Built On
Margo Gladding on
Eating less shouldn't mean getting less of what your body needs. These four supplements cover the gaps, in every phase.
Key takeaways
One doesn’t have a single nutritional deficit, as eating less leaves you with small gaps across multiple nutrients, which is why there are four products as the foundation rather than one.
The Core 4: a high-quality multivitamin, vitamin D3 with K2, a synbiotic, and magnesium.
Leading medical and nutrition organizations have identified key nutrient priorities during GLP-1 therapy as an ongoing concern, not just an early-months one.
For most people, the Core 4 is the whole supplement plan. Everything else is added only when there's a specific reason.
Not sure which phase you're in, or what to add on top of the foundation?
The Most Common Question We Hear, and Why It's the Wrong One First
One of the most common questions we hear is: "What supplements should I take while I'm on Ozempic or Wegovy?"
It's an important question. But it's not the first one.
It’s not that eating less usually leads to a single nutrient deficiency. It results in multiple minor nutrient deficiencies at once.
It’s not one supplement that’s the answer. It’s the base.
The GLP-1 drugs work by cutting down on how much you eat. That’s how they can help you lose weight, and that’s also what causes those gaps: less protein, vitamins and minerals, fluids, and electrolytes get to a body that still requires all of them. Many people don’t have any symptoms as they occur.
We didn’t find any of this to be shocking. Medications which interfere with nutrient absorption and utilization have been in pharmacy stores for years and addressing this sort of nutrient deficiency has been something we’ve done for a very long time. GLP-1’s are just another example, perhaps the largest example yet.
The medication changes how much you eat. It doesn't change what your body still needs.
Think of the Core 4 vitamins to take while on Ozempic as the nutritional foundation that stays with you from your first injection through long-term maintenance, and even as you transition off medication.
Nutrient Depletion Isn't New to Us
Long before GLP-1s were available, we were already focused on making sure our clients get back the things that the medications are silently robbing them of. More than 60 years of watching how medications and nutrients affect each other gives us a strong basis for the Core 4 based on both scientific evidence and real world clinical experience. And it’s why we always start with less, not more.
Your Nutritional Foundation: Meet the Core 4
1. High-quality multivitamin
The broadest net you could possibly throw is a multivitamin.
Best for:
Broad nutrient coverage
Everyday energy
Immune function
The wide-ranging gaps that open when you eat less
Why it matters. It covers the vitamins and minerals your body draws on every day for energy, immune function, tissue repair, and metabolism, rather than leaving you to guess which specific gap opened up.
What to look for. Active and bioavailable forms of vitamins and minerals; methylated B vitamins and chelated minerals rather than cheap generic versions. A vitamin designed for women should provide iron up until menopause as well as extra support for bones.
What we recommend. Our Pathway Essentials Coenzymated Multivitamins use B vitamins in their active, ready-to-use forms, no conversion required. Three options, so you can choose the one that fits:
→ Coenzymated Advanced Men's Multi
→ Coenzymated Pro Advanced Women's Multi, accounts for iron needs before menopause
→ Coenzymated Once Daily Multi, No Iron, for anyone who doesn't need supplemental iron, or takes it separately
2. Vitamin D3 with K2
Best for:
Bone health
Immune support
Muscle function
Steady support for long-term GLP-1 use
Why it matters. The link between Ozempic and vitamin D matters because insufficiency is already widespread before treatment begins. Weight loss shifts how your bones remodel, a process that depends on steady vitamin D. K2 works alongside D3 to help direct calcium where it's needed most.
Look for D3 (cholecalciferol) rather than D2, combined with K2. You should know what your level is. If you have it tested, use that information to determine your dose.
What we recommend. Pathway Essentials Vitamin D3 + K2 pairs cholecalciferol with vita MK-7, the well-researched MK-7 form of K2. It comes in two strengths so you can match your intake to your needs, and it's the one Core 4 supplement where bloodwork, not guesswork, should drive the dose. Our team can help you interpret yours.
3. Synbiotic
Best for:
Digestion
Gut comfort
Microbiome balance
The gut changes that start in week one
Why it matters. GLP-1 medications shift how your gut moves from the earliest weeks, and those changes continue throughout treatment. A comprehensive synbiotic, probiotics with prebiotic and postbiotic support, helps maintain gut barrier health and a balanced microbiome, which support healthy digestion and nutrient absorption.
What to look for: Clinically-studied ingredients, multiple strains with significant CFU count, along with a prebiotic fiber to feed them.
What we recommend. Humanized Nutrition Pro Advanced Synbiotic is built for exactly this job. It delivers all three layers of gut support in one daily capsule: clinically studied probiotic strains, the prebiotic fiber that feeds them, and the postbiotic compounds that support your gut barrier.
4. Magnesium
Best for:
Sleep
Energy
Muscle function
Stress resilience
Why it matters. Magnesium supports hundreds of essential processes throughout the body, and it's one of the nutrients most likely to fall short as food intake decreases. It supports muscle function, energy, sleep quality, stress resilience, and regularity, all of which come under more pressure during treatment.
What to look for. Magnesium glycinate is usually the most easily tolerated form, and most helpful for sleep and stress resistance. Magnesium oxide is widely available, and cheap, but not very well absorbed.
What we recommend. Pathway Essentials Magnesium Glycinate 400 mg, gentle on a stomach that's already digesting slowly, well absorbed, and the form best suited to sleep and stress support, which is why we suggest taking it in the evening. Available in two sizes, depending on whether you'd rather restock often or stock up.
How to Take Your Core 4
Supplement |
When to take it |
On a GLP-1, this matters because |
Multivitamin |
Food: improves absorption and reduces stomach upset, which is more important if you’re not absorbing nutrients quickly. |
Covers the wide range of nutrient deficiencies you face when you eat less in general |
Vitamin D3 + K2 |
With your largest meal, it's fat-soluble, so some fat helps it absorb |
Supports the bone remodeling that rapid weight loss speeds up, and levels are often low before you even start |
Synbiotic |
The benefits of use accumulate over time and are most beneficial when you don't miss a day, so not worrying about the exact time of day is probably more important than getting it right. |
Supports the gut, which shifts in the first few weeks of being on a GLP-1 and plays a role in digestion and nutrient uptake. |
Magnesium glycinate |
In the evening 30-60 mins before bedtime, the glycinate form supports relaxation. So this form works well at night. |
It replaces one of the first minerals to be depleted with insufficient intake and promotes sleep and regularity, which can get more difficult over time. |
Why We Chose These Four
Leading medical and nutrition organizations have identified key nutrient priorities during GLP-1 therapy as an ongoing concern, not just an early-months one. These are the same gaps the Core 4 is designed to fill.
That does not mean everyone on a GLP-1 will be deficient. It means that the odds of being deficient rise significantly when you’re eating significantly less and universal, blanket coverage is the right answer for a known problem. The advisory tells us nothing we do not already know. We have been doing the work for decades to help people replace what they are missing due to their medications.
Start Here. For Most People, This Is All You Need.
The Core 4 addresses the deficiencies that occur for virtually everyone taking a GLP-1. It’s not just the first 4 items on a much longer list. It’s the entire plan.
The order of importance is: food first. The Core 4 supplements are to fill in any gaps that food doesn't. And then if there's a reason to take additional things such as a particular stage, need, or symptom, then add that in.
We'd rather you take four things well than ten things halfway. So if you're wondering whether you need more than the foundation, there's an easy way to find out. Take the assessment, or have a quick chat with our team of nutrition experts.
The other three give you some decisions to make: what’s the best multivitamin for you, how much vitamin D do you need, what dose of magnesium should you stockpile? The base layer is common to all, but the ingredients filling it out aren’t. Why not just build your whole base layer in one place?
What Sits on Top of the Foundation
The Core 4 is what doesn’t change. Beyond that, some phases need just one or two extra items, but only if those aren’t already being provided by the food and the core. No one person needs all of these, but you’ll want to include the two that apply to your phase (if any are needed).
The Core 4 remains unchanged. For some phases, you'll have an extra one or two supplements to consider, but only if food alone isn't meeting that need. Only take what's required for your phase.
Phase |
Possible Phase-Specific Support |
Phase 1 · Just Starting |
Digestive support + active B12 |
Phase 2 · Actively Losing |
Creatine monohydrate + collagen peptides |
Phase 3 · Plateau |
Stress support + therapeutic-dose omega-3 |
Phase 4 · Maintenance |
Creatine monohydrate + therapeutic-dose omega-3 |
Phase 5 · Transitioning Off |
Blood sugar support + appetite control |
The foundation stays the same. The support evolves with your body.
Not Sure Where to Start?
Regardless of what stage you are in, the base will be the same, and it is the first place to start.
Still not sure if you need more than the Core 4? Get a free GLP-1 Nutrition Assessment that identifies your phase in about two minutes. Your results will include your nutrition goals for protein, fiber, and hydration, priority add-ons if you need them, lifestyle habits worth prioritizing, and what to focus on today.
Get Your Personalized Phase Report ►
If you want a program that’s based purely on you, we have our Clinical Nutrition Program. It involves personal consultations, complete review of health histories and lab work, and customized treatment programs.
Book a Nutrition Consultation ►
GLP-1 medications can be powerful. But eating less shouldn't mean getting less of what your body needs.
Start with your foundation. Then follow your phase.
Frequently Asked Questions
What supplements should not be taken with Ozempic?
The short answer is: nothing in the Core 4 needs to be avoided on a GLP-1. What we do steer people away from are the transdermal or oral "natural GLP-1" dietary supplements marketed as boosters. A 2026 pharmacology analysis flagged these as unlawful and potentially risky. Real support comes from covering nutrient gaps, not from products claiming to mimic your medication.
Does Ozempic cause vitamin deficiency?
It is associated with an increased risk, though, right? In a real-world study of over 461,000 adults taking GLP-1s, nearly 1 in 5 developed a nutrient deficiency in the first year. The most common was vitamin D, followed by iron and B vitamins. And many patients were completely asymptomatic during the development of these deficiencies. So, that is why we need broad, steady coverage as the baseline.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. The information in this article is educational and is not a substitute for advice from your healthcare provider.
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PATHWAY
Coenzymated Pro Advanced Women’s Multi
No reviews
$27.21
$38.87
Coenzymated Pro Advanced Women’s Multi is a high-potency, once-daily multivitamin featuring fully methylated B vitamins (B-12, B-6, Folate) for superior absorption. With antioxidants, botanicals, and minerals to support women’s energy, detoxification, and metabolic health. Non-GMO, vegetarian, and gluten-free.
Methylated B vitamins have a direct impact on metabolism, as well as supporting detoxification of hormonal pathways. Methylated B vitamins also aid the absorption of other nutrients. Those with the MTHFR enzyme polymorphism do not convert these much-needed B Vitamins into their active form. A whole host of health issues can ensue from the deficiencies that result. The methylation of B vitamins is important to the endocrine system, metabolism, and the circulatory system. Methylated B vitamins support stress, detoxification, inflammation response, energy production, and homocysteine production. This is why a methylated Multivitamin is and should be a regular part of many people’s daily supplement routine. Coenzymated Pro Advanced Women’s Multi provides the more active forms of Folic Acid, B-12 and B-6 so the body can utilize these nutrients faster.
Features:
High potency once daily formula contains B-Complex with fully methylated 1000 mcg of B-12 (as Methylcobalamin), 1020 mcg DFE Folate (as Magnafolate C 5-MTHF), 80 mg of BenfoPure Benfotiamine, and 25 mg of B-6 (as Pyridoxal-5-Phosphate).
Provides effective doses of BenfoPure Benfotiamine, XanMax Lutein & Zeaxanthin, Grape Seed Extract, Quercetin, Lycopene, Cranberry Fruit Extract, Alpha Lipoic Acid, Niacin, Thiamin, Riboflavin, Biotin, Pantothenic Acid, L-OptiZinc and a full spectrum of Minerals.
Alpha Lipoic Acid for added antioxidant support
Contains No Dairy, Wheat, Gluten, Eggs, Peanuts, Soy, Tree Nuts, Fish, Shellfish, Sesame, Preservatives, Artificial Colors or Flavors
No Iron, Gluten Free, Non GMO and Vegetarian
Benefits:
Delivers the most bioactive forms of B-12, Folic Acid and B-6 for faster and more complete absorption and assimilation.
Methylcobalamin and Magnafolate C (Methylfolate) help support healthy red blood cell formation, which is essential for transporting oxygen, healthy brain function and liver detoxification. Works with P-5-P to aid the normal production of healthy myelin, which protects the nervous system and its function.
Addresses the deficiencies of B-12, Folic Acid and B-6 that increase with age because of decreased levels of intrinsic factor, a protein normally produced by the stomach, aiding B12 absorption.
BenfoPure Benfotiamine is a fat-soluble derivative of thiamine (vitamin B1). With Alpha Lipoic Acid, Benfotiamine supports healthy blood sugar levels and may help with nerve and kidney function, especially in people with high blood sugar. It is considered more bioavailable and metabolically active than traditional thiamine.
XanMax Lutein & Zeaxanthin, Grape Seed Extract, Quercetin, Lycopene and Cranberry Fruit Extract to better nourish & protect a woman’s health and wellness.
Suggested Use:
As a dietary supplement, adults take two (2) vegetarian capsules daily or as directed by a healthcare professional.
Storage Instruction:
Store in a cool, dry place away from direct light.
Warning:
Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6.
Keep this product out of reach of children.
In case of accidental overdose, call a doctor or poison control center immediately.
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PATHWAY
Coenzymated Advanced Men's Multi
No reviews
$27.21
$38.87
Coenzymated Advanced Men’s Multi is a high-potency, once-daily multivitamin featuring fully methylated B-vitamins, antioxidants, and BenfoPure for optimal absorption and metabolic performance. Formulated for daily energy and long-term wellness, it supports blood sugar, prostate, and nerve health. Non-GMO, vegetarian, and gluten-free.
Methylated B vitamins play a key role in metabolism, nutrient absorption, and the detoxification of hormonal pathways. Individuals with MTHFR enzyme variations cannot efficiently convert standard B vitamins into their active forms, leading to potential deficiencies that impact energy, circulation, and overall metabolic health. By supplying pre-activated forms of folate (B9), B12, and B6, Advanced Coenzymated Men’s Multi ensures optimal utilization for improved stress resilience, detoxification, inflammation balance, and energy production.
Features:
High potency once daily formula contains B-Complex with fully methylated 1000 mcg of B-12 (as Methylcobalamin), 80 mg of BenfoPure Benfotiamine, 680 mcg DFE Folate (as Magnafolate C 5-MTHF) and 25 mg of B-6 (as Pyridoxal-5-Phosphate).
Provides effective doses of BenfoPure Benfotiamine, XanMax Marigold Extract (20% Free Lutein: 4% Zeaxanthin Complex, Powder), L-OptiZinc, Saw Palmetto Berry Extract, Pumpkin Seed Powder, Grape Seed Extract, Niacin, Thiamin, Riboflavin, Biotin, Pantothenic Acid and supportive nutrients like Lycopene and Quercetin.
Contains No Dairy, Wheat, Gluten, Eggs, Peanuts, Soy, Tree Nuts, Fish, Shellfish, Sesame, Preservatives, Artificial Colors or Flavors
No Iron, Gluten Free, Non GMO and Vegetarian
Benefits:
Delivers the most bioactive forms of vitamins B12, B6, and folate for faster, more complete absorption and utilization.
Methylcobalamin and Magnafolate C (methylfolate) support healthy red blood cell formation which is critical for oxygen transport, brain health, and liver detoxification, and work with P-5-P to maintain healthy myelin and nervous system function.
Addresses age-related declines in B-vitamin absorption due to reduced intrinsic factor production, helping maintain optimal levels of B12, folate, and B6.
BenfoPure Benfotiamine, a fat-soluble form of vitamin B1, supports healthy blood sugar metabolism and nerve and kidney function, especially when combined with Alpha Lipoic Acid. It is more bioavailable and metabolically active than standard thiamine.
Lycopene, Quercetin, Saw Palmetto Extract, and Pumpkin Seed Powder work synergistically to support prostate health and help manage mild to moderate urinary symptoms.
Suggested Use:
As a dietary supplement, adults take two (2) vegetarian capsules daily, or as directed by a healthcare professional.
Storage Instruction:
Store in a cool, dry place away from direct light.
Warning:
KEEP OUT OF REACH OF CHILDREN.
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PATHWAY
Coenzymated Once Daily Multi, No Iron
No reviews
$29.03
$41.47
Methylated B vitamins have a direct impact on metabolism, as well as supporting detoxification of hormonal pathways. Methylated B vitamins also aid the absorption of other nutrients. Those with the MTHFR enzyme polymorphism do not convert these much-needed B Vitamins into their active form, and the resulting deficiencies can lead to a number of health issues. The methylation of B vitamins is important to the endocrine system, metabolism, and the circulatory system. Methylated B vitamins support stress, detoxification, inflammation response, energy production, and homocysteine production. This is why a methylated multivitamin is and should be a regular part of many people’s daily supplement routine. Coenzymated Once Daily Multi provides the more active forms of Folic Acid, B-12 and B-6, so the body can utilize these nutrients faster.
Features:
A high potency, once daily formula containing B-Complex with fully methylated 250 mcg of B-12 (as Methylcobalamin), 680 mcg DFE Folate (as MagnafolateC 5-MTHF) and 10 mg of B-6 (as Pyridoxal-5-Phosphate).
Provides effective dose of flush-free Niacin (Inositol Hexanicotinate), Thiamin, Riboflavin, Biotin, Pantothenic Acid, as well as supportive nutrients like Copper, Zinc, and Magnesium.
Alpha Lipoic Acid for added antioxidant support
No Iron, Gluten Free, Non GMO and Vegan
Contains no sugar, dairy, wheat, gluten, eggs, peanuts, soy, tree nuts, fish, shellfish, preservatives, artificial colors or flavors.
Benefits:
Delivers the most bioactive forms of B-12, Folic Acid, and B-6 for faster and more complete absorption and assimilation.
Necessary for the estimated 30% of the population that has MTHFR mutation, which causes the body to struggle with the methylation process.
Ideal source for vegan/vegetarians who are at greater risk for vitamin B-12 and Folic Acid deficiency.
Methylcobalamin and MagnafolateC (Methylfolate) help support healthy red blood cell formation, which is essential for transporting oxygen throughout the body.
Methylcobalamin helps donate a methyl group to form SAMe (s-adenosylmethionine) which supports healthy brain function and liver detoxification.
P-5-P and MagnafolateC aid the normal production of healthy myelin, which protects the nervous system and it’s function.
Methylcobalamin helps support fatty acid, amino acid and carbohydrate metabolism.
Addresses the deficiencies of B-12, Folic Acid, and B-6 that increase with age due to decreased levels of intrinsic factor, a protein normally produced by the stomach, which aids in B12 absorption.
Suggested Use:
As a dietary supplement, adults take one (1) vegetarian capsule daily or as directed by a healthcare professional.
Storage Instructions:
Store in a cool, dry place away from direct light
KEEP OUT OF REACH OF CHILDREN.
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PATHWAY
Vitamin D3 Plus K2
4 reviews
$22.39
$31.99
Promotes Bone and Cardiovascular HealthOptimal amounts of vitamins D and K are essential for bone, cardiovascular, and immune health. These two vitamins work synergistically by helping to properly utilize calcium within the body. Vitamin D is necessary for calcium absorption, and vitamin K is important for directing calcium to the bones and away from the soft tissues, such as blood vessels. Taking Vitamin D and K in combination can provide greater support for the body than taking them separately. Suggested Use: 1 capsule daily
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PATHWAY
Vitamin D3 PLUS K2 125MCG
No reviews
$19.66
$28.08
Vitamins D3 and K2 are both fat-soluble vitamins with similar structures that provide many benefits to the body. The synergistic relationship helps properly utilize calcium within the body, from the absorption to the binding of calcium to bones. Vitamin D3 plays a main role in regulating calcium metabolism by increasing intestinal calcium absorption. Vitamin K2 is essential for binding newly absorbed calcium to the mineral matrix in bone. Studies have shown that vitamin K2 is the more bioavailable form of the nutrient and influences bone building more powerfully than K1.The mechanism of action of Vitamins D3 and K2 not only enhances bone strength and structure, but also helps to improve cardiovascular health by removing excess calcium from the bloodstream.
Features
Contains higher potency (125mcg) Vitamin D3 (cholecalciferol), a highly bioavailable form of Vitamin D.
Contains higher potency (100mcg) vitaMK7® Vitamin K2 (menaquinone-7), derived from the biofermentation process of the Bacillus subtilis ssp natto, without chemical compounds.
Free of the major food allergens – Contains No sugar, dairy, wheat, gluten, eggs, peanuts, soy, tree nuts, fish, shellfish, sesame, preservatives, artificial colors or flavors.
Non-GMO and Vegetarian
Benefits
Vitamins D3 and K2 support bone mineralization and lower fracture risk.
Vitamins D3 and K2 play a key role in supporting the cardiovascular system as well as blood sugar balance already within normal levels.
Vitamin K2 provides critical cardiovascular protection by helping to activate matrix GLA protein (MGP), an inhibitor of circulatory calcification.
Studies have shown that both Vitamins D3 and K2 are associated with a stronger immune function and help to balance the inflammatory response.
Vitamins D3 and K2 help to support a strong protein matrix for bone mineralization.
Helps maintain adequate blood calcium levels, which help support cellular metabolic processes, cardiovascular and neuromuscular/neurological function.
Vitamins D3 and K2 support the health and elasticity of arterial walls.
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HUMANIZED NUTRITION
Pro Advanced Synbiotic
No reviews
$51.77
$73.95
Pro Advanced Synbiotic is a next-generation gut health formula combining prebiotics, probiotics, and postbiotics for comprehensive digestive and immune support. Features EpiCor®, ButyraGen™, and PoZibio® for microbiome balance, GLP-1 support, and optimal gut function.
Nearly 30% of Americans report that gut health is an ongoing challenge, with one-third experiencing abdominal discomfort a few times each month and nearly 40%, especially women, are struggling with bloating. To address these issues, half of consumers turn to non-prescription solutions, and 41% already take probiotics. In fact, one in five Americans has experimented with multiple approaches to improve digestive well-being. While prebiotic and probiotic combinations have become commonplace, consumers are now seeking a more advanced, comprehensive solution. Postbiotics are the beneficial compounds produced by inactivated microorganisms and they represent the next evolution in gut health. These science-backed ingredients deliver measurable benefits without the challenges of live cultures, and interest is high: research shows 50% of all consumers and 91% of probiotic users are eager to try a postbiotic.
Features
PREBIOTIC and PROBIOTIC supplying:
100 mg ButyraGen™ Tributyrin
100 mg Inulin (from Jerusalem artichoke [Helianthus tuberous] root)
20mg LP-116 Lactobacillus plantarum 10 Billion CFU
POSTBIOTIC supplying:
500 mg EpiCor® Saccharomyces cerevisiae
100 mg PoZibio® Lactobacillus paracasei
5 mg Akkermansia (Pasteurized Akkermansia muciniphila) 1 billion TFU
Contains no sugar, salt, dairy, wheat, gluten, eggs, peanuts, soy, tree nuts, fish, shellfish, sesame, preservatives, artificial colors or flavors
Gluten Free, Non-GMO and Vegan
Benefits
Clinically studied ingredients provide Gut Health and GLP-1 Support.
EpiCor® – a leading postbiotic made from Saccharomyces cerevisiae – delivers a unique blend of beneficial metabolites and bioactive compounds. Backed by 15 published studies and multiple human clinical trials, EpiCor® has been shown to help support immune and gut health.
ButyraGen™ Tributyrin is a prebiotic which generates butyrate in the gut independent of the state of the microbiome and contributes to gut lining integrity, digestion, and microbial balance.
Chicory Inulin is a soluble fiber and source of fructo-oligosaccharide that has a prebiotic effect, acts as a soluble fiber, increases probiotic fermentation, and enhances calcium absorption.
LP-116 Lactobacillus plantarum is a probiotic strain naturally found in the gut and fermented foods like sauerkraut and sourdough that helps support digestive balance and immune function. Research suggests it may reduce occasional bloating, strengthen the intestinal barrier, and support healthy lipid metabolism.
PoZibio® is a scientifically backed, patented ingredient that limits inflammation in the gut lining, while promoting healthy digestion and nutrient absorption, immunity, the gut-brain axis, and gastro-discomfort.
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PATHWAY
Magnesium Glycinate 400Mg
4 reviews
$18.89
$26.99
Highly Absorbable Magnesium
Magnesium plays an essential role in hundreds of cellular reactions in they body, and is considered one of the most important minerals. In the U.S., magnesium deficiency is common, and can result from depleted soil, digestive issues, chronic diseases, and medication use. Symptoms of magnesium deficiency include leg cramps, insomnia, muscle pain, anxiety, high blood pressure, blood sugar imbalances, fatigue, migraines, and osteoporosis. Pathway Magnesium Glycinate is a chelated form of magnesium which provides high levels of absorption and bioavailability and is an ideal recommendation for individuals wanting to correct a magnesium deficiency.
Suggested Use: 3 capsules daily
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PATHWAY
MAGNESIUM GLYCINATE 400 MG
No reviews
$42.13
$60.19
Magnesium garners less attention than many other minerals but may be one of the body’s most important essential nutrients. While many nutrients are vital to a few biological processes, magnesium is essential for hundreds of them. It is critical for foundational processes such as carbohydrate and protein synthesis, the movement of other minerals across cell membranes, cellular energy production, synthesis of RDA and DNA, nerve impulse contraction, muscle contraction, the regulation of blood pressure, maintenance of normal heart rhythm, to name a few. Although it is present in many fresh, unprocessed foods, magnesium is lacking in highly-processed foods that make up the majority of the diets of people all over the world. In the absence of a healthy diet, dietary supplementation with magnesium may be advisable to ensure one’s proper health. Magnesium glycinate is highly absorbable and bioavailable and is one of the most efficient ways of adding magnesium to the diet.
Features:
Superior Absorption & Bioavailability. Chelation with glycine changes local pH and significantly enhances absorption. Magnesium glycinate is not dependent on gastric acid for absorption.
400 mg of Magnesium per serving.
Soy, and Dairy Free.
Gluten Free • Non GMO • Vegan
Benefits:
In the decades-long Framingham Heart Study, higher magnesium levels were associated with a significantly lower chance of calcification of coronary and abdominal arteries.
Higher intake of magnesium is associated with a reduction in the occurrence of arrhythmia. Magnesium is also used as a clinical intervention in certain types of ventricular arrhythmias.
National Institutes of Health issued findings that higher magnesium levels in the blood are strongly associated with a lower risk of cardiovascular disease.
Magnesium helps the body respond quickly to stress, and helps give the body a deep sense of relaxation.
Magnesium is critical for the relaxation of the smooth muscles, including those found in blood vessels.
Higher magnesium intake is associated with a lower risk of atherosclerosis.
Reductions in magnesium levels have been linked to increased levels of anxiety.
Magnesium is essential for maintaining normal, healthy blood pressure.
Magnesium a cofactor in hundreds of enzymatic processes, including the activities of hormones, neurotransmitters, and other cellular regulators.
Magnesium is required for certain processes involving ATP, DNA, and RNA.
Suggested Use:
As a dietary supplement, adults take 3 vegan capsules daily, or as directed by a health care professional.
Storage Instructions:
Store in a cool, dry place
Keep away from direct light
KEEP OUT OF REACH OF CHILDREN.
References
- NIH Office of Dietary Supplements, Vitamin D Fact Sheet for Health Professionals
- NIH Office of Dietary Supplements, Vitamin K Fact Sheet for Health Professionals
- NIH Office of Dietary Supplements, Magnesium Fact Sheet for Health Professionals
- NIH Office of Dietary Supplements, Multivitamin/Mineral Supplements Fact Sheet
- Current Developments in Nutrition, Plant-Based Nutrition During GLP-1 Therapy
- NIH Office of Dietary Supplements, Vitamin B12 Fact Sheet for Health Professionals
- Transdermal "Natural GLP-1" Dietary Supplements Violate Law and Place Patients at Risk (Ann Pharmacother, 2026)
- MedlinePlus, Semaglutide Injection
- Nutritional priorities to support GLP-1 therapy for obesity: a joint advisory from the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and The Obesity Society (Obesity, 2025)
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