Nattokinase: Heart Health & Clot-Busting Benefits

Nattokinase is an enzyme that is derived from a traditional Japanese food called natto. Natto is made by fermenting soybeans with a specific strain of bacteria known as Bacillus subtilis var. natto. During the fermentation process, this bacterium produces nattokinase, which is responsible for many of natto's unique properties. Nattokinase offers a wide range of potential health benefits, particularly in the area of cardiovascular health.

Health Benefits of Nattokinase

Dissolves Clots

It is not yet known whether nattokinase can break up blood clots in humans, and existing research shows inconsistent findings. A 2021 randomized controlled trial (RCT), known as the Nattokinase Atherothrombotic Prevention Study, investigated whether nattokinase could reduce subclinical atherosclerosis in healthy, older adults. The study found no significant effect. Despite promising findings from animal and cell culture experiments, such results are not necessarily reproducible in humans. So while there is reason for optimism, we should approach these results with realistic expectations.

How does nattokinase work?

Nattokinase has been shown to dissolve blood clots using a property known as fibrinolytic activity. Here's how it works: blood clots are formed when a protein called fibrin binds together, creating a mesh that traps blood cells. Nattokinase steps in as a natural clot buster by breaking down fibrin, thus preventing and dissolving clots. This remarkable ability can help reduce the risk of conditions like deep vein thrombosis (DVT) and stroke.

In the research literature, you'll also see nattokinase called subtilisin NAT. That name reflects its source, Bacillus subtilis var. natto. It's a good reminder that this enzyme doesn't act in isolation.

Promotes Cardiovascular Health

One of the most well-documented uses of nattokinase is its potential to promote cardiovascular health. Here's how it can benefit your heart:

1. Blood pressure regulation: Studies suggest that nattokinase may help lower blood pressure. It achieves this by improving blood flow and reducing the stiffness of blood vessels, ultimately lessening the strain on your heart.

2. Improved circulation: Nattokinase may help support circulation through its anti-platelet effects, which have been studied for reducing blood viscosity and platelet aggregation. This means that your blood flows more smoothly through your vessels, reducing the risk of clot formation and related cardiovascular issues.

3. Cardiovascular disease prevention: By improving blood flow, reducing clot formation, and lowering blood pressure, nattokinase can contribute to a reduced risk of heart disease and stroke. It's a natural ally in the fight against these common and potentially deadly conditions.

4. Anti-inflammatory effects: Some research suggests that nattokinase possesses anti-inflammatory properties, which further supports its cardiovascular benefits. Chronic inflammation is a risk factor for heart disease, and nattokinase may help mitigate this risk.

Nattokinase is a natural enzyme with great potential to support cardiovascular health and reduce the risk of blood clots. While more research is needed to fully understand its benefits, the existing evidence is promising. If you're interested in exploring nattokinase as a part of your wellness routine, remember to consult with a healthcare professional for personalized guidance. With its clot-busting abilities and potential cardiovascular benefits, nattokinase may just be the heart-healthy addition you've been searching for.

Research on natto heart health is ongoing, and a 2022 clinical trial of 1,062 patients found that nattokinase was beneficial in improving atherosclerosis progression and hyperlipidemia. However, because studies are different in design, you should consult with your practitioner to find out if nattokinase may be right for you.

Results differ from one study to another, but we still recommend that you consult your doctor first.

Nattokinase and Blood Thinners

At Village Green, we are often asked, “Is it safe to take nattokinase with my blood thinner?” That question warrants a full discussion. Because nattokinase has been shown to have fibrinolytic and anti-platelet properties, it might increase the effect of anticoagulants, aspirin, or other natural products. If you are taking any type of blood thinner, do not start taking nattokinase without first discussing it with your prescribing physician. If you have a bleeding disorder or upcoming surgery, nattokinase is not for you either.

From Natto to Supplement

Natto is definitely an acquired taste. It’s sticky and stringy and pungent… yet it’s still a common breakfast food in Japan. If you like it, natto may have a place in your whole-food diet and your heart health routine. Keep in mind that natto is also a great dietary source of vitamin K2, which you want to avoid if you’re taking the blood thinner warfarin. Since supplements extract the nattokinase enzymes from the natto soybeans, you’re getting the enzyme but not the food. Unsure about what you’re reading on a label? Contact us!

Nattokinase and Clot Risk

Here is a question we get asked at the counter more often than you would think. Since nattokinase acts on clots, can it cause a clot? There are studies that have looked at nattokinase and its effect on fibrinolysis. That means it may help support the body's natural breakdown of fibrin, the protein mesh that holds a clot together, rather than building it up. However, safety concerns in the research lean the opposite way, toward bleeding. This is particularly true when nattokinase or similar products are used with anticoagulants (blood thinners) or aspirin. In other words, the main safety issue appears to be bleeding, not clotting. If you have a clotting problem, a history of clots, or are taking any blood thinners, consult your prescriber before using nattokinase.

Frequently Asked Questions

Does nattokinase prevent blood clots?

No supplement can promise that. Nattokinase isn't approved to prevent any condition. It has been studied for its fibrinolytic activity. That means it may help support the body's natural breakdown of fibrin. If you're at risk for clots, your doctor's plan comes first.

Does nattokinase thin blood?

This doesn’t function like a prescription blood thinner, but it’s not neutral, either. Nattokinase is associated with anti-platelet effects and may help support healthy blood viscosity. Which is why it shouldn't be taken along with blood thinners or aspirin unless directed by your prescriber.

Does natto dissolve blood clots?

Yes, nattokinase is found in natto, but you wouldn't use it as a treatment for a blood clot. If you have a suspected blood clot, you should get immediate medical attention. Natto is a delicious fermented food to enjoy in your diet, but it is high in vitamin K2, which will interfere with warfarin.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.